Background and aim: Lung cancer is one of the most leading causes of cancer death in males and females and the second leading cause of cancer death. Epigenetic alterations, including DNA hypermethylation, histone deacetylation, and miRNAs lead to the silencing of tumor suppressor genes (TSGs) resulting in tumorigenesis. This change has been reported in various cancers. The activity of DNA meth...

Background and Aim: Morphine is frequently used for patients suffering cancer in their end stages to relive pain. However, there are conflicting reports suggesting morphine to promote tumor growth and reduce survival rate in cancerous animal models or induce necrosis and apoptosis in the tumor cells. In the present study, we studied the effect of morphine on proliferation of human lung adenocar...

Background & Aims: Lung cancer is the most common cancer in men and the main cause of male cancer deaths worldwide. Also, it is the second leading cause of cancer deaths in women worldwide. In this study, we replaced miRNA145 in lung cancer cells by vector based miRNA-145, then the level of miRNA expression in these cells increased and we investigated the effects of the miRNA on inhibition of m...

Introduction: Silica nanoparticles have received more attraction in medical and industrial applications due to their unique properties such as small size, the possibility of surface functionalization, ease of production, and low cost. So, it is necessary to study the respiratory toxicity of occupational exposure due to the production and increasing use of silica nanoparticles, especially in the...

Lung cancer is a very aggressive and most deadly cancer in both men and women. Lung cancer is divided into two types of small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). NSCLC is divided into 3 subgroups: adenocarcinoma (AC), squamous cell carcinoma (SqCC) and large cell carcinoma (LCC). Dopamine is involved in controlling motions, cognition, emotions, memory and reward mech...